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The Promises Treatment Centers, estimates that between five and 10 % of the patients at his centers are given naltrexone. Those most likely to receive it are people with a history of early relapse—anyone who has been treated before and possess not had time to maintain sobriety for much more than four weeks. Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done so that the public understands the side effects and risks of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on his or her medications. Researchers found that participants taking this drug for the year, dropped a few pounds within one month and have kept the weight off through the entire 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which can be made up of several active ingredient, that might make them far better and safer. Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that since right now there aren't long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug can also raise blood pressure levels and pulse rate, and must not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must not used in patients with uncontrolled high blood pressure levels, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. Acamprosate also functions eliminate the desire to drink by reducing the the cravings for drinking alcohol. The major difference between Naltrexone and Acamprosate is Acamprosate is just not yet available in the United States. While it has become widely studied in Europe the complete chemical belief that it works is still unknown. It is belief that it disrupts receptors inside brain which process glutamate, which essentially alters just how ones body reacts to alcohol intake. Several of the European research shows a lot of promise with Acamprosate because some of the patients had an almost double effectiveness for staying sober.