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The drugs, acamprosate (marketing name: Campral) and naltrexone (ReVia) were found to help those struggling in different phases of recovery. Acamprosate helped manage emotional triggers in people that had already stopped drinking, naltrexone helped manage cravings in heavy drinkers who are looking to stop drinking or recently quit. Using two separate drugs to lose weight naturally can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err on the side of caution and let the FDA do its job and demand some research be done so the public understands the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on the medications. Researchers found out that participants taking this drug for the year, dropped excess weight within one month and have kept the load off throughout the 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which may make them more potent and safer. Combo-pilling may be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that as of right now there aren't long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug may also raise hypertension and heart rate, and must not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. Other people who must avoid using Contrave are patients suffering from bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for females who are pregnant or trying to become pregnant.